| Slow-wave sleep in mammals is characterized by a change of large-scale cortical activity currently paraphrased as cortical up/down states. Recently Shu et al. demonstrated experimentally a bistable collective behavior in ferret slices, with the remarkable property that up states can be switched on and off with pulses, or excitations, of same polarity; whereby the effect of the second pulse significantly depends on the time interval between the pulses. We present a time discrete model of a neural network that reproduces this type of stimulation response and quantitatively the time-dependence found in the experiments. |
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