Effects of base-pairs fluctuations on long-range charge transport in DNA
S. Komineasa,b, G. Kalosakasa,
and A.R. Bishopa aTheoretical Division and Center for Nonlinear Studies,
Los Alamos National Laboratory, Los Alamos, NM 87545 bPhysikalisches Institut, Universitaet Bayreuth,
D-95440 Bayreuth, Germany
Abstract
We investigate the propagation of a charge carrier along a dynamically
disordered double-stranded DNA. This is realized by the coupling of the
charge with a nonlinear lattice model that can
efficiently describe the statistical mechanics of the large amplitude
fluctuations of the base pairs leading to the denaturation transition
of DNA. We found that a large denaturation bubble can trap the charge
and inhibit the polaronic transport. The dependence of the mean distance
covered by the charge carrier until its pinning, as a function of
the energy of the random thermal fluctuations of the base pairs is
also presented.