Max-Planck-Institut für Physik komplexer
Systeme
International Workshop on
Biological Evolution and Statistical
Physics
May 10-14, 2000
The Statistical Reconstruction of the Past: Drawing
Inferences Independently of Phylogeny
Mark Pagel
Division of Zoology
School of Animal & Microbial
Sciences
PO Box 228, University of
Reading
READING, RG6 6AJ
m.pagel@reading.ac.uk
I shall discuss how to use statistcial models of evolution
to arrive at probabilitic inferences about the most likely ancestral character
states of genes, proteins, or other traits that organisms may have had
millions of years ago. Such inferences must always be drawn with
respect to a probable genealogy or phylogeny of the organisms. And yet,
it is desirable to make the final inference independent of any one phylogenetic
hypothesis, which itself may be flawed. I show how markov-chain monte
carlo techniques make this possible, and how they make it possible to assess
independent evidence for the truth of one's inferences about the past.
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