Duplication and Rearrangement in Genome Evolution
Dannie Durand 
Department of Molecular Biology, Princeton University 
        Princeton, NJ 08544 
        durand@molbio.princeton.edu

 
Duplication of large genomic regions, ranging from chromosomal segments to the entire genome, is believed to have played a crucial role in developmental innovation in vertebrates.  While many isolated examples of evolution through gene duplication in mammals exist, the large-scale events - duplication, rearrangement and gene loss - that led to the spatial organization of modern mammalian genomes are poorly understood.  I describe a computational, genome-wide approach to finding duplicated genes and discuss methods for reconstructing the history of large-scale duplications and rearrangements from
this data.  I will conclude by describing the biological and computational innovations that made bioinformatic studies like this one possible and discuss the scientific opportunities that await us as this technology grows.

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